{{ (moduleVm.actions && moduleVm.changeStatus) ? moduleVm.status : '' }} Oral Gonadotrophin-Releasing Hormone Antagonists for the Treatment of Uterine Leiomyomas *6181*
Activity Steps
Description
Cognate Code 6181Learning Objectives
After completing this continuing education activity you will be able to:
- List common symptoms of uterine leiomyomas that would suggest the need for medical intervention.
- Outline the process by which oral gonadotropin-releasing hormone (GnRH) antagonists provide rapid suppression of sex steroids and avoid the initial steroidal flare and resultant temporary worsening of symptoms typically seen with parenteral GnRH agonists.
- Discuss the role of add-back therapy in the treatment of patients with symptomatic uterine leiomyomas.
- Implement clinical strategies to integrate evolving knowledge in this field into your own clinical practice.
Disclosures
Financial Disclosure: Elizabeth A. Stewart reports money was paid to her institution from AHRQ/PCORI for grant P50 HS023418 and from Eunice Kennedy Shiver Institute of Child Health and Human Development, National Institutes of Health CC, for grant R01HD105714 regarding adenomyosis CC. She received payment from Bayer. She has served as consultant for AbbVie, ObsEva, and Myovant related to uterine fibroids and oral GnRH antagonists, but those companies did not support this project. She holds a patent for Methods and Compounds for Treatment of Abnormal Uterine Bleeding (US 6440445), which has no commercial activity. She has received royalties from UpToDate and payments for the development of educational content from the Med Learning Group, PER, Massachusetts Medical Society, and Peer View. She also serves as an unpaid advisor to the Fibroid Foundation. Michael F. Neblett II did not report any potential conflicts of interest. Elizabeth A. Stewart also reported that Linzagolix is discussed in this article as the third oral GnRH antagonist in development for the treatment of uterine leiomyomas, since it is approved for use in the EU despite being labeled as investigational in the United States.
Credits:
- ACOG 2.0 CME